Intravaginal and intrarectal microbicides to prevent HIV infection

Intravaginal and intrarectal microbicides to prevent HIV infection.

Use of intravaginal microbicides to prevent acquisition of Trichomonas vaginalis infection in Lactobacillus-pretreated, estrogenized young mice.

D2A21, a novel peptide antibiotic has in vitro activity against a wide spectrum of sexually transmitted diseases (STD). In this study we tested the hypothesis that intravaginal D2A21 would interfere with acquisition of Trichomonas vaginalis infection in a modified mouse model. T. vaginalis infections of estrogenized young mice pretreated with Lactobacillus vaginalis or Lactobacillus rhamnosus w...

Microbicides for the Prevention of HIV Infection

Preventive interventions beyond behavior modification and physical barrier methods are needed to alter the natural course of the global HIV epidemic. Women need HIV-prevention tools that they can control to safeguard their health and that of their families and communities. This review focuses on one of the most promising prevention tools currently under development, namely microbicides. Microbi...

Rectal Microbicides that Protect Against HIV Infection

High Infection Rates for Adult Macaques after Intravaginal or Intrarectal Inoculation with Zika Virus

Unprotected sexual intercourse between persons residing in or traveling from regions with Zika virus transmission is a risk factor for infection. To model risk for infection after sexual intercourse, we inoculated rhesus and cynomolgus macaques with Zika virus by intravaginal or intrarectal routes. In macaques inoculated intravaginally, we detected viremia and virus RNA in 50% of macaques, foll...